Treponema species cause treponemal diseases such as syphilis, bejel, pinta and yaws.
T. pallidum pallidum is a motile spirochaete that is generally acquired by close sexual contact. The organism can also be transmitted to a fetus by transplacental passage during the later stages of pregnancy, causing congenital syphilis. The subspecies causing yaws, pinta, and bejel are morphologically and serologically indistinguishable from T. pallidum pallidum (syphilis). However, their transmission is not venereal in nature and the course of each disease is significantly different.
- Syphilis is transmitted through sexual contact or from mother to fetus during pregnancy or at birth. The signs and symptoms of syphilis vary depending on which of the four stages it is present in (primary, secondary, latent, and tertiary). The primary stage typically starts with a single chancre (a firm, painless, non-itchy skin ulceration), secondary syphilis with a diffuse rash which frequently involves the palms of the hands and soles of the feet, latent syphilis with little to no symptoms, and tertiary syphilis with gummas (growths), neurological, or cardiac symptoms.
- Yaws is an infection of the skin, bones and joints transmitted by skin to skin contact. The bacteria enter the skin through a scratch or cut and become infected. This becomes a painless nodule which enlarges and becomes warty in appearance. Left untreated, warty nodules can appear all over the body as time progresses.
- Pinta is thought to be transmitted by skin to skin contact. After an incubation period of two to three weeks, it produces a raised papule which enlarges and becomes scaly/flaky. Within three to nine months it thickens and flat lesions appear all over the body. These generally resolve, but a portion of people with pinta will further develop late-stage disease, characterized by pigment changes with a mixture of hyperpigmentation and depigmentation which can be disfiguring.
- Bejel usually begins in childhood as a small mucous patch, often on the interior of the mouth, followed by the appearance of raised, eroding lesions on the limbs and trunk. Periostitis (inflammation) of the leg bones is common and gummas (growth) of the nose and soft palate develop in later stages.
This Quantum Formula antidotes the various species in the Treponema genus and all of its subspecies.