Exophiala is a widespread fungus commonly found in soil and sewage. It causes mycetoma and opportunistic infections in humans. This organism is recognized with increasing frequency as a cause of human disease. Human infection caused by Exophiala can be separated into three types: superficial infections, cutaneous and subcutaneous disease, and visceral or systemic disease.

Most cases of infection caused by Exophiala are included in the first two categories. Visceral or systemic disease is very rare. Cases of pneumonia, fungaemia, central nervous system infection, endocarditis and peritonitis have been reported. Systemic diseases have occurred mostly in patients with predisposing factors such as organ transplant, leukemia, cystic fibrosis, HIV infection and dialysis, catheter-related infection and cystic fibrosis.

Researchers tested home dishwashers and found Exophiala in 62% of them.